What is Ipamorelin and how does it work according to research

Ipamorelin or NNC 26-0161, a polypeptide hormone, is a growth hormone secretagogue and ghrelin mimetic and analogue developed by Novo Nordisk.

Ipamorelin belongs to the most recent generation of GHRPs from the mid 1990s and causes significant release of growth hormone by itself, due both to its suppression of somatostatin (an antagonist to GHRH) and stimulation of release of GH from the anterior pituitary, similar to GHRP-2 and GHRP-6 which are compounds from the same class (growth hormone releasing peptides). The cells that produce and release GH are known as somatotropes. Ipamorelin acts synergistically when applied during a native GHRH (growth-hormone-releasing hormone) pulse or when co-administered with GHRH or a GHRH analogue such as Sermorelin or GRF 1-29 (growth releasing factor, amino 1-29).

The synergy comes both due to the suppression of somatostatin and the fact that ipamorelin increases GH release per-somatotrope, while GHRH increases the number of somatotropes releasing GH. There is also a secondary effect of neuronal excitation in the hypothalamus caused by ipamorelin, which lasts for approximately 3 hours after application, similar to GHRP-2 and GHRP-6.

Research shows.

Ipamorelin has a unique property among the GHRP class of peptides. That property is known as selectiveness. Whereas GHRP-6 and GHRP-2 cause a release and increase in cortisol and prolactin levels, ipamorelin only selectively releases GH at any dose.

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References / Links

1. Bowers, C. Y., Momany, F., Reynolds, G. A., Hong, A., Chang, D., & Chang, K. (1996). Ipamorelin, a novel pentapeptide growth hormone secretagogue: comparative studies with GHRP-6 and GHRP-2 in vitro and in vivo. Endocrinology, 137(2), 535–543. PubMed
2. Raun, K., Hansen, B. S., Johansen, N. L., Thøgersen, H., Madsen, K., Ankersen, M., & Andersen, P. H. (1998). Ipamorelin, the first selective growth hormone secretagogue. European Journal of Endocrinology, 139(5), 552–561. PubMed
3. Johansen, N. L., Raun, K., Hansen, B. S., Thøgersen, H., Madsen, K., Ankersen, M., & Andersen, P. H. (1999). Pharmacological profile of ipamorelin, the first selective growth hormone secretagogue. European Journal of Endocrinology, 141(2), 180–189. PubMed
4. Ghigo, E., Arvat, E., Giordano, R., & Camanni, F. (1997). Growth hormone–releasing peptides. European Journal of Endocrinology, 136(5), 445–460. PubMed