Sleep Enhancement Research

Peptide GHRP-6, also known as growth hormone-releasing peptide 6, is a synthetic hexapeptide that specifically stimulates natural growth hormone release from the anterior pituitary gland by pituitary somatotrophs. It acts by binding to ghrelin receptors and mimics the effects of ghrelin – natural endogenous hormone. It has been researched for several...

Ipamorelin represents a synthetic pentapeptide derived from GHRP-1, which has a very potent growth hormone (GH) releasing properties with efficacy and potency comparable to GHRP-6, both in vitro and in vivo. Unlike other GH secretagogues, ipamorelin very surprisingly does not induce a significant increase in adrenocorticotropic hormone (ACTH) or cortisol...

Hexarelin, also known as Examorelin, is a synthetic GH releasing hexapeptide, which activates growth hormone secretagogue receptor (GHSR) in the brain area. It is also ghrelin analog, similarly to other peptides such as GHRP-6. Beyond GH release and neuroendocrine effects, hexarelin might have also direct cardiovascular actions and cardioprotective...

Tesamorelin is one of synthetically produced growth hormone releasing hormone (GHRH) analogues, which is utilized in the treatment of HIV-associated lipodystrophy, a condition characterized by abnormal fat distribution due to antiretroviral therapy in HIV-infected patients. By activating GHRH receptors in the pituitary gland, tesamorelin stimulates the...

Peptide GHRP-2, also known as pralmorelin, is a synthetic hexapeptide, one of the first growth hormone secretagogues, that is known for its muscle growth increasing, ghrelin stimulating, immune system strengthening or sleep improving properties shown in numerous researches. GHRP-2 activates the release of growth hormone (GH) by binding to the growth...

Mod GRF 1-29 is a synthetic peptide identical to CJC-1295 without DAC compound. It is truncated analogue of growth hormone releasing hormone (GHRH), which was developed in 1980s from original GRF 1-29, but with purposefully prolonged half-life to ensure better therapeutical use. This modified version was shown to have similar or even the same effects as...

CJC-1295+DAC is one of modified synthetic analogues of growth hormone releasing hormone (GHRH). It acts as a growth hormone (GH) secretagogue stimulating levels of GH and insulin-like growth factor 1 (IGF-1), while preserving GH pulsatility. This stimulation in turn is the basis for its effects confirmed in various studies in animals and humans. This...

DSIP (Delta Sleep-Inducing Peptide) is a structurally short neuropeptide of natural origin that influences a number of endocrine as well as physiological processes in the central nervous system. It was first isolated in 1970s from cerebral venous blood of rabbit brains during slow-wave sleep. It is of great interest for its effects and ability to induce...