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What is Hexarelin and how does it work according to studies

Due to Hexarelin ability to increase secretion of natural Growth Hormone, most of its effects are similar to those of synthetic GH, although to a slightly lesser extent. Effects of its use include: increase in strength, the growth of new muscle fibres, increase in the size of already existing muscle fibres, neural protection, joint rejuvenation, protection and healing. Also, the GH receptors in adipose (fat) tissue allow for potential fat reduction with Hexarelin use. The increase of circulating GH through Hexarelin use causes levels of Insulin-Like Growth Factor (IGF-1) to rise in the liver. IGF-1 is the prime cause of muscle growth in response to GH stimulation.

There is no appetite boost with Hexarelin use (as opposed to GHRP-6’s extreme appetite increase) due to its inability to drastically increase Ghrelin levels that are responsible for added hunger and quicker gastric emptying.

In studies where Hexarelin was injected subcutaneously, Growth Hormone, measured through plasma concentrations, increased significantly and within thirty minutes of injection. GH levels decreased back to normal around four hours post injection. The GH increase has been found to be effective up to 2mg/kg, any further increase in dose was found to be ineffective in causing a GH response.

Research showed that Hexarelin’s effect on GH stimulation tapered between weeks 4 through 16. Separating cycles by 4 weeks off periods, avoiding the negative feedback loop and the next cycle of Hexarelin produced the same level of results as the first cycle.

Hexarelin (Hexarelin Acetate) is a synthetic hexapeptide in the growth factor family which stimulates the release of growth hormone (GH) and does not interfere with the body’s ability to produce its own GH. Structurally, Hexarelin (Hexarelin Acetate) is similar in structure to GHRP-6 but without the appetite increase because of its inability to drastically increase Ghrelin levels which is responsible for the increased appetite and quicker gastric emptying. Hexarelin is a synthetic growth hormone secretagogue made from six amino acids. It contains powerful growth hormone releasing properties in the human body. Hexarelin in studies over a certain period has shown that it reduces visceral fat. Hexarelin (Hexarelin Acetate) like other Growth Hormone Releasing Peptides is most effective synergistically when administered with GHRH such as Sermorelin or Modified GRF 1-29.

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THE GOODS OFFERED BY THE SELLER IS INTENDED FOR SCIENTIFIC AND DEVELOPMENT PURPOSES ONLY. The goods offered by the Seller include chemical substances that shall not be used as a drug, medicine, active substance, medical aid, cosmetic product, a substance for production of a cosmetic product neither for human consumption that is any food or food supplement or otherwise similarly used on humans or animals.


References / Links

  1. Bowers, C. Y., Momany, F. A., Reynolds, G. A., Chang, D., Hong, A., & Chang, K. (1984). On the in vitro and in vivo activity of a new synthetic hexapeptide that acts on the pituitary to specifically release growth hormone. Endocrinology, 114(5), 1537–1545. PubMed
  2. Ghigo, E., Arvat, E., Gianotti, L., Imbimbo, B. P., Lenaerts, V., Deghenghi, R., & Camanni, F. (1994). Growth hormone-releasing activity of Hexarelin, a new synthetic hexapeptide, in man. Journal of Clinical Endocrinology & Metabolism, 78(4), 693–698. PubMed
  3. Arvat, E., Gianotti, L., Broglio, F., & Ghigo, E. (1997). Hexarelin, a synthetic hexapeptide, is a potent GH secretagogue in humans. Journal of Endocrinological Investigation, 20(9), 521–526. PubMed
  4. Camanni, F., Ghigo, E., & Arvat, E. (1998). Growth hormone-releasing peptides and their analogs. Frontiers in Neuroendocrinology, 19(1), 47–72. PubMed
  5. Bowers, C. Y. (1998). Growth hormone-releasing peptide (GHRP). Cellular and Molecular Life Sciences, 54(12), 1316–1329. PubMed

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