The GHRP peptide group: from strongest to weakest according to research

GHRP-6 is known for being a big appetite stimulator, but it is not the strongest GH releasing peptide in the GHRP family. There are other members of the GHRP family we should briefly look at.

This list is in order from strongest to weakest.

1. Hexarelin – The strongest in the family known to give the biggest pulse of all. Will create prolactin and cortisol side effects. Desensitization will happen regardless of the dose.

2. GHRP-2 – Second in the category, however, desensitization is unclear if used beyond saturation dose.

3. GHRP-6 – Third in the lineup for potency, and when shots are broken up, desensitization does not occur. Slightly creates prolactin and cortisol issues.

4. Ipamorelin – This mildest in the bunch, does not create prolactin or cortisol and at very large doses was shown to give a large release of GH without desensitization.

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References / Links

1. Bowers, C. Y., Momany, F., Reynolds, G. A., Chang, D., Hong, A., & Chang, K. (1984). On the in vitro and in vivo activity of a new synthetic hexapeptide that acts on the pituitary to specifically release growth hormone. Endocrinology, 114(5), 1537–1545. PubMed
2. Ghigo, E., Arvat, E., Gianotti, L., Imbimbo, B. P., Lenaerts, V., Deghenghi, R., & Camanni, F. (1994). Growth hormone-releasing activity of Hexarelin, a new synthetic hexapeptide, in man. Journal of Clinical Endocrinology & Metabolism, 78(4), 693–698. PubMed
3. Bowers, C. Y. (1998). Growth hormone-releasing peptide (GHRP). Cellular and Molecular Life Sciences, 54(12), 1316–1329. PubMed
4. Ghigo, E., Arvat, E., Gianotti, L., Broglio, F., & Camanni, F. (1997). Growth hormone-releasing peptides. European Journal of Endocrinology, 136(5), 445–460. PubMed
5. Jönsson, J. O., Eden, S., Kvist, O., Isaksson, O. G., & Bengtsson, B. A. (1998). Ipamorelin, the first selective growth hormone secretagogue. European Journal of Endocrinology, 139(5), 552–561. PubMed