MOTS-c: The Mitochondrial Key to Energy and Longevity

Unhealthy habits, such as excessive calorie intake or a sedentary lifestyle, often lead to metabolic disorders and premature ageing. The search for effective and innovative solutions is becoming an urgent challenge, and MOTS-c is emerging as one of the most promising candidates for revolutionary change.

MOTS-c, short for mitochondrial open reading frame of the 12S rRNA type-c, is a peptide encoded in mitochondrial DNA. Its discovery has represented a fundamental breakthrough in the understanding of mitochondrial signalling and its impact on the overall health of the body.

What makes MOTS-c special is its ability to mimic the effects of exercise. It activates metabolic pathways similar to those that are naturally triggered during physical activity. MOTS-c is a logical step for anyone who wants to support his/her metabolism and live to a ripe old age in the best possible health.

MOTS-c and optimisation of the metabolic performance

The therapeutic potential of MOTS-c is confirmed by several experimental studies. Scientists from the University of California administered the peptide to mice fed a high-fat diet and monitored them closely to see what would happen. The results were stunning – despite the high-fat diet, the mice not only did not gain weight, but even lost body weight.

Another study examined the effects of MOTS-c on ovariectomised female mice to model the hormonal instability of the postmenopausal period. Administration of the peptide activated brown adipose tissue, leading to increased energy expenditure while reversing the development of insulin resistance.

In addition to regulating metabolism, MOTS-c increases bone density and strength. It supports the differentiation of mesenchymal stem cells into osteoblasts, which are cells responsible for the formation of new bone tissue. It opens up new possibilities in the prevention of osteoporosis, which threatens the health of millions of women around the world every year.

Cardiologists became alert when laboratory models of vascular calcification responded to administration of MOTS-c. The peptide activated AMPK prevented calcium deposition in the arteries and preserved vascular elasticity. For athletes, this translates to better blood circulation, more efficient oxygen supply to muscles and higher physical performance.

A study by California scientists showed impressive results. After a two-week treatment with MOTS-c, older rodents outperformed younger ones in a running test. The peptide increased PGC-1α expression, expanded the mitochondrial network and, together with training, also enhanced glucose transport via GLUT4.

MOTS-c increases ATP production, accelerates lactate breakdown and shortens the time required for recovery. For the sports segment, this is a unique bio-hack that brings real performance benefits.

Longevity and a life full of energy

Longevity experts consider MOTS-c to be the "guardian of cellular youth". Studies have shown that this peptide activates gene pathways that are responsible for cell repair and regeneration. Like NAD+ or resveratrol, MOTS-c acts at the mitochondrial level, but it excels in its significantly faster effect without the formation of side metabolites.

In 2021, scientists demonstrated that regular administration of MOTS-c improves mobility parameters in older individuals. The increase in muscle endurance and decrease in inflammation give the peptide a reputation as the “healthy ageing molecule”. In practice, this means a longer period of active life and more time for doing your favourite activities.

The safety profile of MOTS-c also convinced the professional public. Studies have shown excellent tolerance without any serious adverse effects. However, experts recommend to use certified and verified sources to ensure maximum product purity and minimise the risk of any complications.

MOTS-c could pave the way for those who refuse to settle for average and instead of passively accepting change, seek an active path to health and longevity. Vitality, energy and physical performance do not necessarily decline with age if modern knowledge about the regulation of metabolism at the cellular level is utilised.

SOURCES

https://pubmed.ncbi.nlm.nih.gov/25738459/

https://pubmed.ncbi.nlm.nih.gov/30725119/

https://pubmed.ncbi.nlm.nih.gov/32182209/

https://pubmed.ncbi.nlm.nih.gov/24533934/

https://pubmed.ncbi.nlm.nih.gov/33722744/

https://pubmed.ncbi.nlm.nih.gov/33473109/

https://pmc.ncbi.nlm.nih.gov/articles/PMC9570330/