What is GHRP-2 and how does it work according to research

Growth hormone releasing peptide 2 or GHRP 2 is a synthetic analogue of GHRP 6. It is well-known for its ability to effectively improve and stimulate the production of human growth hormone. It also plays a role as a ghrelin activator. Ghrelin is a newly discovered peptide found in the gut. It binds to growth hormone secretagogue receptors as well as promotes food and stomach emptying.

GHRP 2 is a potent hexapeptide similar to GHRP 6. It has been extensively studied for its ability as a GHS (growth hormone secretagogue) or to stimulate the production of growth hormones. It is popular for its capacity to stimulate the release of ghrelin resulting in increased appetite and hunger. This peptide is best used to correct decreased production of growth hormones. It is also able to help unusually lean individuals gain weight. It is also an excellent substance to reverse the effects of ageing amongst persons with low growth hormone levels.

How does GHRP 2 work?

GHRP 2 works by stimulating the pituitary gland’s natural ability to produce endogenous human growth hormone (HGH). It enhances HGH production in two ways – first, it amplifies the transduction pathway of natural growth hormone releasing signal which leads to an increase in growth hormone levels. Second, it inhibits the activities of somatostatin thus bringing about an increase in endogenous growth hormone levels.

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References / Links

1. Bowers, C. Y., Reynolds, G. A., Durham, D., Barrera, C. M., Pezzoli, S. S., & Thorner, M. O. (1990). Growth hormone (GH)-releasing peptide stimulates GH release in normal men and acts synergistically with GH-releasing hormone. Journal of Clinical Endocrinology & Metabolism, 70(4), 975–982. PubMed
2. Bowers, C. Y. (1993). Growth hormone-releasing peptides. Annals of the New York Academy of Sciences, 692(1), 10–21. PubMed
3. Arvat, E., Gianotti, L., Ramunni, J., Maccagno, B., Camanni, F., & Ghigo, E. (1997). Mechanisms underlying the positive synergistic interaction between growth hormone-releasing hormone and hexarelin, a synthetic hexapeptide, in humans. Journal of Clinical Endocrinology & Metabolism, 82(2), 341–345. PubMed
4. Arvat, E., Di Vito, L., Broglio, F., Papotti, M., Muccioli, G., Dieguez, C., Casanueva, F. F., Deghenghi, R., Camanni, F., & Ghigo, E. (2000). Preliminary evidence that Ghrelin, the natural GH secretagogue (GHS)-receptor ligand, strongly stimulates GH secretion in humans. Journal of Clinical Endocrinology & Metabolism, 85(12), 4908–4911. PubMed
5. Smith, R. G., Van der Ploeg, L. H. T., Howard, A. D., Feighner, S. D., Cheng, K., Hickey, G. J., Wyvratt, M. J., & Fisher, M. H. (1997). Peptidomimetic regulation of growth hormone secretion. Endocrine Reviews, 18(5), 621–645. PubMed