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Thymosin beta-4 promotes angiogenesis, wound healing, and hair follicle development.
New blood vessel formation is important in many physiological process, including development, wound repair, and tumor growth. In aged animals, angiogenesis is reduced resulting in poor wound healing. We have identified a novel small molecule, thymosin beta(4), that promotes angiogenesis and wound repair in both normal and aged rodents. It also promotes hair growth in normal and aged rodents. It acts by increasing angiogenesis and cell migration and is currently in clinical trials for wound repair.
The main functionality of Thymosin beta-4 hinges on the ability to up-regulate cell-building proteins like Actin. Up-regulation of Actin allows Thymosin beta-4 to promote cell migration and proliferation. This not only helps build new blood vessel pathways but also regulates inflammation directly correlated with wound healing. Its versatility even extends to its molecular structure and low molecular weight, which lends to its mobility and ability to travel long distances through tissues. This means when targeting injured areas (chronic or acute), Thymosin beta-4 has the ability to circulate the body and find those areas of injury in order to take corrective action. Added benefits of improved flexibility, reduced inflammation in tendons have been noticed, and some users report some re-grown lost hair (also reports of greyed hair darkening).
In fact, studies are being done which correlate Thymosin beta-4 with the healing of the heart, in some cases repairing ventricular hypertrophy.
Warning
THE GOODS OFFERED BY THE SELLER IS INTENDED FOR SCIENTIFIC AND DEVELOPMENT PURPOSES ONLY. The goods offered by the Seller include chemical substances that shall not be used as a drug, medicine, active substance, medical aid, cosmetic product, a substance for production of a cosmetic product neither for human consumption that is any food or food supplement or otherwise similarly used on humans or animals.
References / Links
- Philp, D., et al. (2004). Thymosin beta-4 induces angiogenesis, hair follicle growth, and wound healing. Nature, 432(7016), 466. PubMed Central
- Bock-Marquette, I., et al. (2004). Thymosin beta-4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. Nature, 432(7016), 466–472. PubMed
- Smart, N., et al. (2007). Thymosin beta-4 induces adult epicardial progenitor mobilization and neovascularization. Nature, 445(7124), 177–182. PubMed
- Cavasin, M. A., et al. (2014). Antifibrotic effects of Thymosin beta-4 in the heart. Circulation Research, 114(8), 1425–1436. PubMed
Studies on Thymosin beta-4:
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At Particle Peptides, we believe that reliable research begins with reliable materials. That is why our research peptides are manufactured on cGMP-compliant production lines by a global pharmaceutical CDMO, and every batch undergoes independent third-party testing for:
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- Heavy metals (Class I & II)
- Microbial contamination (TAMC & TYMC)
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