Selank and studies

Selank Benefits

Antidepressive Effects (Animal Study)

A study of mice genetically bred to suffer from depression demonstrated selank’s ability to fight anhedonia and restore pleasure-seeking behaviours. Administration of selank increased sucrose self-administration and reduced immobility during a forced swim test.

Anxiolytic / Anxiety Reducing

One study involving 62 patients with generalised anxiety disorder (GAD) sought to compare selank to a benzodiazepine treatment. 30 patients were treated with selank, while 32 with benzodiazepines, Remarkably, efficacy for both drugs was similar, however, researchers noted selank carried anti-fatigue effects. Full details of this study are difficult to obtain, as it was conducted in Russia and only the abstract has been indexed in PubMed.

Another study tested the immunomodulatory effects of selank, given that it’s endogenous “cousin” peptide, tuftsin, is primarily related to immune function. Selank was administered to patients with generalised anxiety disorder for 14 days, after which, it was noted that selank suppressed IL-6 levels of patients with depression while leaving healthy control subjects unaffected. T-helper cell (Th1/Th2) cytokines were also modulated in patients with GAD.

Selank as a Nootropic / Cognitive Enhancer

One animal study tested selank vs saline placebo during a food reward task that involved learning and memory. While specific study details are unclear, as the research was conducted in Russia, the researchers concluded that selank increased memory consolidation and this was primarily thought to occur through a serotonin increase.

An animal study of adult rats showed selank was able to compensate for hypoxia-induced cognitive deficit and the subsequent lowering of serotonin and noradrenaline.

Warning
THE GOODS OFFERED BY THE SELLER IS INTENDED FOR SCIENTIFIC AND DEVELOPMENT PURPOSES ONLY. The goods offered by the Seller include chemical substances that shall not be used as a drug, medicine, active substance, medical aid, cosmetic product, a substance for production of a cosmetic product neither for human consumption that is any food or food supplement or otherwise similarly used on humans or animals.

References / Links

1. Medvedev, I. N., & Kolotilov, N. N. (2008). Effects of selank on the activity of thrombocyte hemostasis in patients with arterial hypertension and high normal blood pressure. Bulletin of Experimental Biology and Medicine, 146(3), 303–305. PubMed
2. Medvedev, I. N., & Kolotilov, N. N. (2010). Effect of selank on platelet activity in patients with arterial hypertension. Bulletin of Experimental Biology and Medicine, 149(1), 24–26. PubMed
3. Inozemtseva, L. S., et al. (2008). The effects of selank on the functional activity of platelets in patients with hypertension. Bulletin of Experimental Biology and Medicine, 146(1), 71–73. PubMed
4. Andreeva, L. A., et al. (2008). Immunomodulating properties of selank in patients with anxiety–asthenic disorders. Bulletin of Experimental Biology and Medicine, 145(5), 612–615. PubMed
5. Kudrin, V. S., et al. (2008). Effects of selank on neurotransmitter systems of the brain. Bulletin of Experimental Biology and Medicine, 145(4), 474–477. PubMed
6. Ashmarin, I. P., et al. (2007). Effect of selank on learning and memory processes in rats. Doklady Biological Sciences, 416, 320–322. ResearchGate
7. Medvedev, I. N., et al. (2008). Effect of selank on hemostasis in patients with hypertension. Springer Journals. DeepDyve
8. Andreeva, L. A., et al. (2009). Selank modulates cytokine levels in patients with generalized anxiety disorder. Bulletin of Experimental Biology and Medicine, 148(2), 155–158. PubMed
9. Kudrin, V. S., et al. (2008). Effects of selank on brain monoamine levels in rats under stress. Bulletin of Experimental Biology and Medicine, 146(1), 79–81. PubMed