Delta sleep-inducing peptide (DSIP) and studies

DSIP stands for Delta sleep-inducing peptide. This type of peptide is classified as a neuropeptide and it works by inducing spindle and delta EEG activity and by reducing motor activity. This peptide is utilized in order to help people fall asleep and stay asleep. This peptide is popular with bodybuilders who have learned about the power and potential of peptides through their training and supplementation regimens. DSIP lowers basal corticotropin levels and blocks their release. It also makes it easier for the body to release LH (luteinizing hormone). In addition, it makes it simpler for the body to release somatotrophin (and somatoliberin secretions) and to block the production of somatostatin. This peptide may help people to manage stress. In addition, it may have the power to alleviate the symptoms of hypothermia. It’s also known as an effective means of normalizing blood pressure and contractions which are myocardial. As well, it may offer anti-oxidant benefits (slow down cell damage).

The sleep-inducing activity of Delta Sleep-Inducing Peptide (DSIP) and its 13 synthetic analogues has been studied on rabbits with preliminary implanted electrodes. The peptides were injected into the lateral ventricle of the cerebrum. Polygraphic computer monitoring of sleep-wake states was carried out at daytime for 7–12 h. DSIP and most analogues had no statistically significant effect on sleep compared to the control administration of saline to the same animals. [NMeAla2]DSIP and [Pro2]DSIP had a pronounced sleep-inducing effect and reliably increased the proportion of slow-wave sleep by 10–15% on average compared to the control. Several other analogues had a week sleep-inducing effect, increasing the proportion of slow-wave sleep during specific recording time only. [β-Ala2]DSIP significantly suppressed sleep. In addition, this analogue, as well as parent DSIP and four proline-containing nonapeptides, slightly increased the body temperature. The revealed differences may be due to both conformation properties and proteolytic resistance of the studied molecules, and it may reflect their indirect involvement in the control sleep-wake hormonal processes.

References / Links

1. Kovalzon, V. M., et al. (1992). Sleep-wake effects of delta-sleep-inducing peptide (DSIP) and its analogues in rabbits. Neuropeptides, 23(3), 163–170. PubMed
2. Graf, M. V., Kastin, A. J., Sandman, C. A. (1984). Delta sleep-inducing peptide (DSIP): an update. Neuroscience & Biobehavioral Reviews, 8(4), 507–517. PubMed
3. Kastin, A. J., Schally, A. V., Coy, D. H. (1979). Delta sleep-inducing peptide (DSIP): effects on endocrine function. Pharmacology Biochemistry and Behavior, 10(6), 707–710. PubMed
4. Kastin, A. J., Graf, M. V., Sandman, C. A. (1986). Delta sleep-inducing peptide (DSIP): physiology and pharmacology. Neuroendocrinology, 43(2), 99–114. PubMed